When using reflect, arbitrary types can be synthesized. This invalidates
a few assumptions in the interface-lowering pass, that think they can
see all types that are in use in a program and optimize accordingly.
The file size impact depends on the specific program. Sometimes it's
nonexistent, sometimes it's rather hefty (up to 30% bigger). Especially
the samd21 targets seem to be affected, with a 2000-6000 bytes increase
in code size. A moderately large case (the stdlib test) increases by
4%/6%/15% depending on the target.
I hope that this increase could be mitigated, but I don't see an obvious
way to do that.
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